PDF DatasheetHuman TAR DNA-binding protein 43 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TAR DNA-binding protein 43 based upon sequence from Human
Host: QP6761 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TAR DNA-binding protein 43, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6761.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Gly396
Amino Acid Sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TAR DNA-binding protein 43 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TAR DNA-binding protein 43 Protein General Information | |
|---|---|
| Alternate Names | |
| ALS10, TDP-43 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TARDBP |
| Entrez Gene ID | 23435 |
| Ensemble Gene ID | ENSG00000120948 |
| RefSeq Protein Accession(s) | NP_031401.1 |
| RefSeq mRNA Accession(s) | NM_007375.3, XM_017000863.1, XM_017000864.1, XM_017000865.1, XM_017000866.1, XM_017000867.1, XM_017000868.1 |
| UniProt ID(s) | Q13148 |
| UniGene ID(s) | Hs.300624 |
| HGNC ID(s) | HGNC:11571 |
| COSMIC ID Link(s) | TARDBP |
| KEGG Gene ID(s) | hsa:23435 |
| PharmGKB ID(s) | PA36336 |
| General Description of Recombinant Human TAR DNA-binding protein 43 Protein. | |
| DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3′-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3′ UTR. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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