PDF DatasheetHuman Calcineurin B homologous protein 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Calcineurin B homologous protein 3 based upon sequence from Human
Host: QP6772 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Calcineurin B homologous protein 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6772.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly2 – His214
Amino Acid Sequence: GAAHSASEEV RELEGKTGFS SDQIEQLHRR FKQLSGDQPT IRKENFNNVP DLELNPIRSK IVRAFFDNRN LRKGPSGLAD EINFEDFLTI MSYFRPIDTT MDEEQVELSR KEKLRFLFHM YDSDSDGRIT LEEYRNVVEE LLSGNPHIEK ESARSIADGA MMEAASVCMG QMEPDQVYEG ITFEDFLKIW QGIDIETKMH VRFLNMETMA LCH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Calcineurin B homologous protein 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Calcineurin B homologous protein 3 Protein General Information | |
|---|---|
| Alternate Names | |
| CHP3, TSC | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TESC |
| Entrez Gene ID | 54997 |
| Ensemble Gene ID | ENSG00000088992 |
| RefSeq Protein Accession(s) | NP_001161797.1 |
| RefSeq mRNA Accession(s) | NM_001168325.1, NM_017899.3, XM_017019533.1 |
| UniProt ID(s) | Q96BS2 |
| UniGene ID(s) | Hs.525709 |
| HGNC ID(s) | HGNC:26065 |
| COSMIC ID Link(s) | TESC |
| KEGG Gene ID(s) | hsa:54997 |
| PharmGKB ID(s) | PA143485630 |
| General Description of Recombinant Human Calcineurin B homologous protein 3 Protein. | |
| Functions as an integral cofactor in cell pH regulation by controlling plasma mbrane-type Na+/H+ exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma mbrane. Promotes the induction of hatopoietic st cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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