PDF DatasheetHuman TIMM8A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TIMM8A based upon sequence from Human
Host: QP6794 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TIMM8A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6794.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asp97
Amino Acid Sequence: MDSSSSSSAA GLGAVDPQLQ HFIEVETQKQ RFQQLVHQMT ELCWEKCMDK PGPKLDSRAE ACFVNCVERF IDTSQFILNR LEQTQKSKPV FSESLSD
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TIMM8A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TIMM8A Protein General Information | |
|---|---|
| Alternate Names | |
| DDP, MTS, DFN1, DDP1, TIM8, Mitochondrial import inner membrane translocase subunit Tim8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TIMM8A |
| Entrez Gene ID | 1678 |
| Ensemble Gene ID | ENSG00000126953 |
| RefSeq Protein Accession(s) | NP_004076.1 |
| RefSeq mRNA Accession(s) | NM_004085.3 |
| UniProt ID(s) | O60220 |
| UniGene ID(s) | Hs.447877 |
| HGNC ID(s) | HGNC:11817 |
| COSMIC ID Link(s) | TIMM8A |
| KEGG Gene ID(s) | hsa:1678 |
| PharmGKB ID(s) | PA36523 |
| General Description of Recombinant Human TIMM8A Protein. | |
| Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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