PDF DatasheetHuman TLR2 / CD282 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TLR2 / CD282 based upon sequence from Human
Host: QP6800 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TLR2 / CD282, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6800.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Lys19 – Thr588
Amino Acid Sequence: KEESSNQASL SCDRNGICKG SSGSLNSIPS GLTEAVKSLD LSNNRITYIS NSDLQRCVNL QALVLTSNGI NTIEEDSFSS LGSLEHLDLS YNYLSNLSSS WFKPLSSLTF LNLLGNPYKT LGETSLFSHL TKLQILRVGN MDTFTKIQRK DFAGLTFLEE LEIDASDLQS YEPKSLKSIQ NVSHLILHMK QHILLLEIFV DVTSSVECLE LRDTDLDTFH FSELSTGETN SLIKKFTFRN VKITDESLFQ VMKLLNQISG LLELEFDDCT LNGVGNFRAS DNDRVIDPGK VETLTIRRLH IPRFYLFYDL STLYSLTERV KRITVENSKV FLVPCLLSQH LKSLEYLDLS ENLMVEEYLK NSACEDAWPS LQTLILRQNH LASLEKTGET LLTLKNLTNI DISKNSFHSM PETCQWPEKM KYLNLSSTRI HSVTGCIPKT LEILDVSNNN LNLFSLNLPQ LKELYISRNK LMTLPDASLL PMLLVLKISR NAITTFSKEQ LDSFHTLKTL EAGGNNFICS CEFLSFTQEQ QALAKVLIDW PANYLCDSPS HVRGQQVQDV RLSVSECHRT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TLR2 / CD282 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TLR2 / CD282 Protein General Information | |
|---|---|
| Alternate Names | |
| TLR2, CD282, CD282, TIL4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TLR2 |
| Entrez Gene ID | 7097 |
| Ensemble Gene ID | ENSG00000137462 |
| RefSeq Protein Accession(s) | NP_001305716.1 |
| RefSeq mRNA Accession(s) | NM_001318787.1, NM_001318789.1, NM_001318790.1, NM_001318791.1, NM_001318793.1, NM_001318795.1, NM_001318796.1, NM_003264.4, XM_011532215.2, XM_011532216.2, XM_017008573.1, XM_017008574.1, XM_017008575.1, XM_017008576.1 |
| UniProt ID(s) | O60603 |
| UniGene ID(s) | Hs.519033 |
| HGNC ID(s) | HGNC:11848 |
| COSMIC ID Link(s) | TLR2 |
| KEGG Gene ID(s) | hsa:7097 |
| PharmGKB ID(s) | PA36550 |
| General Description of Recombinant Human TLR2 / CD282 Protein. | |
| Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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