PDF DatasheetHuman DR6 / TNFRSF21 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DR6 / TNFRSF21 based upon sequence from Human
Host: QP6815 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DR6 / TNFRSF21, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6815.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Arg371 – Leu655
Amino Acid Sequence: RKSSRTLKKG PRQDPSAIVE KAGLKKSMTP TQNREKWIYY CNGHGIDILK LVAAQVGSQW KDIYQFLCNA SEREVAAFSN GYTADHERAY AALQHWTIRG PEASLAQLIS ALRQHRRNDV VEKIRGLMED TTQLETDKLA LPMSPSPLSP SPIPSPNAKL ENSALLTVEP SPQDKNKGFF VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF DDMLHFLNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH LPDLL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DR6 / TNFRSF21 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DR6 / TNFRSF21 Protein General Information | |
|---|---|
| Alternate Names | |
| DR6, TNFRSF21, DR6, BM-018, CD358 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF21 |
| Entrez Gene ID | 27242 |
| Ensemble Gene ID | ENSG00000146072 |
| RefSeq Protein Accession(s) | NP_055267.1 |
| RefSeq mRNA Accession(s) | NM_014452.4 |
| UniProt ID(s) | O75509 |
| UniGene ID(s) | Hs.443577 |
| HGNC ID(s) | HGNC:13469 |
| COSMIC ID Link(s) | TNFRSF21 |
| KEGG Gene ID(s) | hsa:27242 |
| PharmGKB ID(s) | PA37775 |
| General Description of Recombinant Human DR6 / TNFRSF21 Protein. | |
| Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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