PDF DatasheetHuman TNFSF12 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TNFSF12 based upon sequence from Human
Host: QP6819 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TNFSF12, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6819.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ser43 – Gln149
Amino Acid Sequence: SLGSRASLSA QEPAQEELVA EEDQDPSELN PQTEESQDPA PFLNRLVRPR RSAPKGRKTR ARRAIAAHYE VHPRPGQDGA QAGVDGTVSG WEEARINSSS PLRYNRQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TNFSF12 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFSF12 Protein General Information | |
|---|---|
| Alternate Names | |
| TNFSF12, Apo3l, Dr3l, Tweak, Dr3lg | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFSF12 |
| Entrez Gene ID | 407977 |
| Ensemble Gene ID | ENSG00000239697 |
| RefSeq Protein Accession(s) | NP_003800.1 |
| RefSeq mRNA Accession(s) | NM_003809.2, NM_172089.3 |
| UniProt ID(s) | O43508 |
| UniGene ID(s) | Hs.54673 |
| HGNC ID(s) | HGNC:11927 |
| COSMIC ID Link(s) | TNFSF12 |
| KEGG Gene ID(s) | hsa:407977 |
| PharmGKB ID(s) | PA162406662 |
| General Description of Recombinant Human TNFSF12 Protein. | |
| Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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