PDF DatasheetHuman TP53-regulated inhibitor of apoptosis 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TP53-regulated inhibitor of apoptosis 1 based upon sequence from Human
Host: QP6841 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TP53-regulated inhibitor of apoptosis 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6841.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser76
Amino Acid Sequence: MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE GLEFMGHGKE KPENSS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TP53-regulated inhibitor of apoptosis 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TP53-regulated inhibitor of apoptosis 1 Protein General Information | |
|---|---|
| Alternate Names | |
| MDM35, P53CSV, WF-1, HSPC132 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRIAP1 |
| Entrez Gene ID | 51499 |
| Ensemble Gene ID | ENSG00000170855 |
| RefSeq Protein Accession(s) | NP_057483.1 |
| RefSeq mRNA Accession(s) | NM_016399.2 |
| UniProt ID(s) | O43715 |
| UniGene ID(s) | Hs.69499 |
| HGNC ID(s) | HGNC:26937 |
| COSMIC ID Link(s) | TRIAP1 |
| KEGG Gene ID(s) | hsa:51499 |
| PharmGKB ID(s) | PA143485661 |
| General Description of Recombinant Human TP53-regulated inhibitor of apoptosis 1 Protein. | |
| Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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