PDF DatasheetHuman Transcription intermediary factor 1-alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcription intermediary factor 1-alpha based upon sequence from Human
Host: QP6842 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcription intermediary factor 1-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6842.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Lys891 – Lys1012
Amino Acid Sequence: KKKTEGLVKL TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Transcription intermediary factor 1-alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transcription intermediary factor 1-alpha Protein General Information | |
|---|---|
| Alternate Names | |
| TIF1, TIF1ALPHA, RNF82, PTC6, hTIF1, TF1A, TIF1A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRIM24 |
| Entrez Gene ID | 8805 |
| Ensemble Gene ID | ENSG00000122779 |
| RefSeq Protein Accession(s) | NP_003843.3 |
| RefSeq mRNA Accession(s) | NM_003852.3, NM_015905.2 |
| UniProt ID(s) | O15164 |
| UniGene ID(s) | Hs.490287 |
| HGNC ID(s) | HGNC:11812 |
| COSMIC ID Link(s) | TRIM24 |
| KEGG Gene ID(s) | hsa:8805 |
| PharmGKB ID(s) | PA36519 |
| General Description of Recombinant Human Transcription intermediary factor 1-alpha Protein. | |
| Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at ‘Lys-4’ (H3K4me0) and acetylated at ‘Lys-23’ (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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