PDF DatasheetHuman TRPA1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TRPA1 based upon sequence from Human
Host: QP6843 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TRPA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6843.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile957 – Pro1119
Amino Acid Sequence: IGLAVGDIAE VQKHASLKRI AMQVELHTSL EKKLPLWFLR KVDQKSTIVY PNKPRSGGML FHIFCFLFCT GEIRQEIPNA DKSLEMEILK QKYRLKDLTF LLEKQHELIK LIIQKMEIIS ETEDDDSHCS FQDRFKKEQM EQRNSRWNTV LRAVKAKTHH LEP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TRPA1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TRPA1 Protein General Information | |
|---|---|
| Alternate Names | |
| FEPS, ANKTM1, Transient receptor potential cation channel subfamily A member | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRPA1 |
| Entrez Gene ID | 8989 |
| Ensemble Gene ID | ENSG00000104321 |
| RefSeq Protein Accession(s) | NP_015628.2 |
| RefSeq mRNA Accession(s) | NM_007332.2, XM_011517625.2, XM_017013946.1 |
| UniProt ID(s) | O75762 |
| UniGene ID(s) | Hs.716816 |
| HGNC ID(s) | HGNC:497 |
| COSMIC ID Link(s) | TRPA1 |
| KEGG Gene ID(s) | hsa:8989 |
| General Description of Recombinant Human TRPA1 Protein. | |
| Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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