PDF DatasheetHuman Ubiquitin D Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ubiquitin D based upon sequence from Human
Host: QP6862 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ubiquitin D, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6862.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gly165
Amino Acid Sequence: MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAC YCIGG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ubiquitin D Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ubiquitin D Protein General Information | |
|---|---|
| Alternate Names | |
| GABBR1, UBD-3, FAT10 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | UBD |
| Entrez Gene ID | 10537 |
| Ensemble Gene ID | ENSG00000213886 |
| RefSeq Protein Accession(s) | NP_006389.2 |
| RefSeq mRNA Accession(s) | NM_006398.3 |
| UniProt ID(s) | O15205 |
| UniGene ID(s) | Hs.44532 |
| HGNC ID(s) | HGNC:18795 |
| COSMIC ID Link(s) | UBD |
| KEGG Gene ID(s) | hsa:10537 |
| PharmGKB ID(s) | PA38682 |
| General Description of Recombinant Human Ubiquitin D Protein. | |
| Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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