PDF DatasheetHuman Ubiquitin carboxyl-terminal hydrolase 14 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ubiquitin carboxyl-terminal hydrolase 14 based upon sequence from Human
Host: QP6873 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ubiquitin carboxyl-terminal hydrolase 14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6873.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln494
Amino Acid Sequence: MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK SLIDQFFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDMYELCT PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK YEPFSFADDI GSNNCGYYDL QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY GPRRVEIMEE ESEQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ubiquitin carboxyl-terminal hydrolase 14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 Protein General Information | |
|---|---|
| Alternate Names | |
| TGT | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | USP14 |
| Entrez Gene ID | 9097 |
| Ensemble Gene ID | ENSG00000101557 |
| RefSeq Protein Accession(s) | NP_001032411.1 |
| RefSeq mRNA Accession(s) | NM_001037334.1, NM_005151.3 |
| UniProt ID(s) | P54578 |
| UniGene ID(s) | Hs.464416 |
| HGNC ID(s) | HGNC:12612 |
| COSMIC ID Link(s) | USP14 |
| KEGG Gene ID(s) | hsa:9097 |
| PharmGKB ID(s) | PA37238 |
| General Description of Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 Protein. | |
| Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chokine receptor CXCR4 which is critical for CXCL12-induced cell chotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.