PDF DatasheetHuman Protein Wnt-5a Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein Wnt-5a based upon sequence from Human
Host: QP6889 protein expressed in E. coli.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein Wnt-5a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6889.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ile62 – Lys380
Amino Acid Sequence: IIGAQPLCSQ LAGLSQGQKK LCHLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNT SVFGRVMQIG SRETAFTYAV SAAGVVNAMS RACREGELST CGCSRAARPK DLPRDWLWGG CGDNIDYGYR FAKEFVDARE RERIHAKGSY ESARILMNLH NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK VGDALKEKYD SAAAMRLNSR GKLVQVNSRF NSPTTQDLVY IDPSPDYCVR NESTGSLGTQ GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT EIVDQFVCK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Protein Wnt-5a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein Wnt-5a Protein General Information | |
|---|---|
| Alternate Names | |
| hWNT5A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | WNT5A |
| Entrez Gene ID | 7474 |
| Ensemble Gene ID | ENSG00000114251 |
| RefSeq Protein Accession(s) | NP_001243034.1 |
| RefSeq mRNA Accession(s) | NM_001256105.1, NM_003392.4, XM_006713324.1, XM_011534085.2, XM_011534086.2, XM_011534087.2, XM_011534088.2, XM_011534089.1, XM_017007128.1 |
| UniProt ID(s) | P41221 |
| UniGene ID(s) | Hs.643085 |
| HGNC ID(s) | HGNC:12784 |
| COSMIC ID Link(s) | WNT5A |
| KEGG Gene ID(s) | hsa:7474 |
| PharmGKB ID(s) | PA37385 |
| General Description of Recombinant Human Protein Wnt-5a Protein. | |
| Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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