PDF DatasheetHuman DNA repair protein XRCC3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA repair protein XRCC3 based upon sequence from Human
Host: QP6893 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA repair protein XRCC3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6893.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg316
Amino Acid Sequence: MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR LREEEAALGC PARTLR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DNA repair protein XRCC3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA repair protein XRCC3 Protein General Information | |
|---|---|
| Alternate Names | |
| CMM6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | XRCC3 |
| Entrez Gene ID | 7517 |
| Ensemble Gene ID | ENSG00000126215 |
| RefSeq Protein Accession(s) | NP_001093588.1 |
| RefSeq mRNA Accession(s) | NM_001100118.1, NM_001100119.1, NM_005432.3, XM_005268046.2, XM_011537138.2 |
| UniProt ID(s) | O43542 |
| UniGene ID(s) | Hs.592325 |
| HGNC ID(s) | HGNC:12830 |
| COSMIC ID Link(s) | XRCC3 |
| KEGG Gene ID(s) | hsa:7517 |
| PharmGKB ID(s) | PA37422 |
| General Description of Recombinant Human DNA repair protein XRCC3 Protein. | |
| Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and ses to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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