PDF DatasheetHuman 2-5A-dependent ribonuclease Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant 2-5A-dependent ribonuclease based upon sequence from: Human
Host: QP6997 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) 2-5A-dependent ribonuclease, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6997.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: His330 – Cys741
Amino Acid Sequence: HPPAEDWKPQ SSHWGAALKD LHRIYRPMIG KLKFFIDEKY KIADTSEGGI YLGFYEKQEV AVKTFCEGSP RAQREVSCLQ SSRENSHLVT FYGSESHRGH LFVCVTLCEQ TLEACLDVHR GEDVENEEDE FARNVLSSIF KAVQELHLSC GYTHQDLQPQ NILIDSKKAA HLADFDKSIK WAGDPQEVKR DLEDLGRLVL YVVKKGSISF EDLKAQSNEE VVQLSPDEET KDLIHRLFHP GEHVRDCLSD LLGHPFFWTW ESRYRTLRNV GNESDIKTRK SESEILRLLQ PGPSEHSKSF DKWTTKINEC VMKKMNKFYE KRGNFYQNTV GDLLKFIRNL GEHIDEEKHK KMKLKIGDPS LYFQKTFPDL VIYVYTKLQN TEYRKHFPQT HSPNKPQCDG AGGASGLASP GC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human 2-5A-dependent ribonuclease Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human 2-5A-dependent ribonuclease Protein General Information | |
|---|---|
| Alternate Names | |
| RNS4, PRCA1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNASEL |
| Entrez Gene ID | 6041 |
| Ensemble Gene ID | ENSG00000135828 |
| RefSeq Protein Accession(s) | NP_066956.1 |
| RefSeq mRNA Accession(s) | NM_021133.3 |
| UniProt ID(s) | Q05823 |
| UniGene ID(s) | Hs.518545 |
| HGNC ID(s) | HGNC:10050 |
| COSMIC ID Link(s) | RNASEL |
| KEGG Gene ID(s) | hsa:6041 |
| PharmGKB ID(s) | PA34418 |
| General Description of Recombinant Human 2-5A-dependent ribonuclease Protein. | |
| Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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