PDF DatasheetHuman Complement C4-B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Complement C4-B based upon sequence from: Human
Host: QP6998 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Complement C4-B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6998.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Glu1454 – Val1744
Amino Acid Sequence: EAPKVVEEQE SRVHYTVCIW RNGKVGLSGM AIADVTLLSG FHALRADLEK LTSLSDRYVS HFETEGPHVL LYFDSVPTSR ECVGFEAVQE VPVGLVQPAS ATLYDYYNPE RRCSVFYGAP SKSRLLATLC SAEVCQCAEG KCPRQRRALE RGLQDEDGYR MKFACYYPRV EYGFQVKVLR EDSRAAFRLF ETKITQVLHF TKDVKAAANQ MRNFLVRASC RLRLEPGKEY LIMGLDGATY DLEGHPQYLL DSNSWIEEMP SERLCRSTRQ RAACAQLNDF LQEYGTQGCQ V
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Complement C4-B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Complement C4-B Protein General Information | |
|---|---|
| Alternate Names | |
| C4B12, C4B3, C4B1, C4F, C4BD, CO4, C4B2, CPAMD3, C4B5, C4B_2, CH | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C4B |
| Entrez Gene ID | 100293534 |
| Ensemble Gene ID | ENSG00000228454 |
| RefSeq Protein Accession(s) | NP_001002029.3 |
| RefSeq mRNA Accession(s) | NM_001002029.3, NM_001242823.2 |
| UniProt ID(s) | P0C0L5 |
| UniGene ID(s) | Hs.534847 |
| HGNC ID(s) | HGNC:1324 |
| COSMIC ID Link(s) | C4B |
| KEGG Gene ID(s) | hsa:100293534 |
| PharmGKB ID(s) | PA25904 |
| General Description of Recombinant Human Complement C4-B Protein. | |
| Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complent pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.Derived from proteolytic degradation of complent C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.