PDF DatasheetS. aureus Iron-regulated surface determinant protein B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Iron-regulated surface determinant protein B based upon sequence from: S. aureus
Host: QP6999 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Staphylococcus aureus (strain USA300 / TCH1516) Iron-regulated surface determinant protein B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6999.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala41 – Thr269
Amino Acid Sequence: AAEETGGTNT EAQPKTEAVA SPTTTSEKAP ETKPVANAVS VSNKEVEAPT SETKEAKEVK EVKAPKETKE VKPAAKATNN TYPILNQELR EAIKNPAIKD KDHSAPNSRP IDFEMKKKDG TQQFYHYASS VKPARVIFTD SKPEIELGLQ SGQFWRKFEV YEGDKKLPIK LVSYDTVKDY AYIRFSVSNG TKAVKIVSST HFNNKEEKYD YTLMEFAQPI YNSADKFKT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of S. aureus Iron-regulated surface determinant protein B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant S. aureus Iron-regulated surface determinant protein B Protein General Information | |
|---|---|
| Alternate Names | |
| ERS445052_02237, AT695_RS12060 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | isdB |
| RefSeq Protein Accession(s) | WP_001041586.1 |
| RefSeq mRNA Accession(s) | NC_010079.1 |
| UniProt ID(s) | P0C7J5 |
| General Description of Recombinant S. aureus Iron-regulated surface determinant protein B Protein. | |
| Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence. IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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