PDF DatasheetEpstein-Barr Latent membrane protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Latent membrane protein 2 based upon sequence from: Epstein-Barr
Host: QP7054 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) Latent membrane protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP7054.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ser147
Amino Acid Sequence: MGSLEMVPMG AGPPSPGGDP DGYDGGNNSQ YPSASGSSGN TPTPPNDEER ESNEEPPPPY EDPYWGNGDR HSDYQPLGTQ DQSLYLGLQH DGNDGLPPPP YSPRDDSSQH IYEEAGRGSM NPVCLPVIVA PYLFWLAAIA ASCFTAS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Epstein-Barr Latent membrane protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Epstein-Barr Latent membrane protein 2 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LMP2 |
| Entrez Gene ID | 17494212 |
| RefSeq Protein Accession(s) | YP_401631.1 |
| RefSeq mRNA Accession(s) | NC_007605.1 |
| UniProt ID(s) | P13285 |
| KEGG Gene ID(s) | vg:17494212 |
| General Description of Recombinant Epstein-Barr Latent membrane protein 2 Protein. | |
| Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs. Isoform LMP2B may be a negative regulator of isoform LMP2A. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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