PDF DatasheetRat Thyroxine 5-deiodinase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Thyroxine 5-deiodinase based upon sequence from: Rat
Host: QP7221 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Thyroxine 5-deiodinase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7221.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Asp37 – Leu278
Amino Acid Sequence: DFLCIRKHFL RRRHPDHPEP EVELNSEGEE MPPDDPPICV SDDNRLCTLA SLKAVWHGQK LDFFKQAHEG GPAPNSEVVR PDGFQSQRIL DYAQGTRPLV LNFGSCTUPP FMARMSAFQR LVTKYQRDVD FLIIYIEEAH PSDGWVTTDS PYVIPQHRSL EDRVSAARVL QQGAPGCALV LDTMANSSSS AYGAYFERLY VIQSGTIMYQ GGRGPDGYQV SELRTWLERY DEQLHGTRPR RL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat Thyroxine 5-deiodinase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Thyroxine 5-deiodinase Protein General Information | |
|---|---|
| Alternate Names | |
| 5DIII; DIOIII | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Dio3 |
| Entrez Gene ID | 29475 |
| RefSeq Protein Accession(s) | NP_058906.3 |
| RefSeq mRNA Accession(s) | NM_017210.4 |
| UniProt ID(s) | P49897 |
| UniGene ID(s) | Rn.11237 |
| COSMIC ID Link(s) | Dio3 |
| KEGG Gene ID(s) | rno:29475 |
| General Description of Recombinant Rat Thyroxine 5-deiodinase Protein. | |
| Responsible for the deiodination of T4 (3,5,3′,5′-tetraiodothyronine) into RT3 (3,3′,5′-triiodothyronine) and of T3 (3,5,3′-triiodothyronine) into T2 (3,3′-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing prature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during bryological development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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