PDF Datasheethepatitis Protein X Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein X based upon sequence from: hepatitis
Host: QP7274 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) Protein X, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7274.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala154
Amino Acid Sequence: MAARLCCQLD PARDVLCLRP VGAESRGRPF SGSLGTLSSP SPSAVPTDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHQILP KVLHKRTLGL SAMSTTDLEA YFKDCLFKDW EELGEEIRLK VFVLGGCRHK LVCAPAPCNF FTSA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of hepatitis Protein X Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant hepatitis Protein X Protein (1-154aa) General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | X |
| UniProt ID(s) | P03165 |
| General Description of Recombinant hepatitis Protein X Protein (1-154aa). | |
| Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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