PDF DatasheetInfluenza Influenza A H3N2 (strain A / England / 878 / 1969) Hemagglutinin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Influenza A H3N2 (strain A / England / 878 / 1969) Hemagglutinin based upon sequence from: Influenza
Host: QP7283 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Influenza A virus (strain A/England/878/1969 H3N2) Influenza A H3N2 (strain A/England/878/1969) Hemagglutinin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7283.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gln1 – Thr328
Amino Acid Sequence: QDLPGNDNST ATLCLGHHAV PNGTLVKTIT NDQIEVTNAT ELVQSSSTGK ICNNPHRILD GINCTLIDAL LGDPHCDVFQ DETWDLFVER SKAFSNCYPY DVPDYASLRS LVASSGTLEF ITEGFTWTGV TQNGGSNACK RGPDSGFFSR LNWLTKSGST YPVLNVTMPN NDNFDKLYIW GVHHPSTNQE QTSLYVQASG RVTVSTRRSQ QTIIPNIGSR PWVRGLSSRI SIYWTIVKPG DVLVINSNGN LIAPRGYFKM RTGKSSIMRS DAPIDTCISE CITPNGSIPN DKPFQNVNKI TYGACPKYVK QNTLKLATGM RNVPEKQT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Influenza Influenza A H3N2 (strain A / England / 878 / 1969) Hemagglutinin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Influenza Influenza A H3N2 (strain A / England / 878 / 1969) Hemagglutinin Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HA |
| UniProt ID(s) | P04664 |
| General Description of Recombinant Influenza Influenza A H3N2 (strain A / England / 878 / 1969) Hemagglutinin Protein. | |
| Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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