PDF DatasheetInfluenza Matrix protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Matrix protein 2 based upon sequence from: Influenza
Host: QP7426 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Influenza A virus (strain A/USA:Phila/1935 H1N1) Matrix protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7426.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ser22
Amino Acid Sequence: MSLLTEVETP IRNEWGCRCN GS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Influenza Matrix protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Influenza Matrix protein 2 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | M2 |
| UniProt ID(s) | A4GCM0 |
| General Description of Recombinant Influenza Matrix protein 2 Protein. | |
| Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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