PDF DatasheetE. coli Translocated intimin receptor Tir Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Translocated intimin receptor Tir based upon sequence from: E. coli
Host: QP7455 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Escherichia coli O157:H7 (strain TW14359 / EHEC) Translocated intimin receptor Tir, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7455.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Gln252 – Gly362
Amino Acid Sequence: QALALTPEPD SPTTTDPDAA ASATETATRD QLTKEAFQNP DNQKVNIDEL GNAIPSGVLK DDVVANIEEQ AKAAGEEAKQ QAIENNAQAQ KKYDEQQAKR QEELKVSSGA G
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of E. coli Translocated intimin receptor Tir Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant E. coli Translocated intimin receptor Tir Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | tir |
| RefSeq Protein Accession(s) | WP_001301454.1 |
| RefSeq mRNA Accession(s) | NC_013008.1 |
| UniProt ID(s) | C6UYL8 |
| KEGG Gene ID(s) | etw:ECSP_4676 |
| General Description of Recombinant E. coli Translocated intimin receptor Tir Protein. | |
| Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The Extracellular domain region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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