PDF DatasheetHuman PRKAB2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PRKAB2 based upon sequence from: Human
Host: QP7495 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PRKAB2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7495.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MGNTTSDRVS GERHGAKAAR SEGAGGHAPG KEHKIMVGST DDPSVFSLPD SKLPGDKEFV SWQQDLEDSV KPTQQARPTV IRWSEGGKEV FISGSFNNWS TKIPLIKSHN DFVAILDLPE GEHQYKFFVD GQWVHDPSEP VVTSQLGTIN NLIHVKKSDF EVFDALKLDS MESSETSCRD LSSSPPGPYG QEMYAFRSEE RFKSPPILPP HLLQVILNKD TNISCDPALL PEPNHVMLNH LYALSIKDSV MVLSATHRYK KKYVTTLLYK PI
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PRKAB2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PRKAB2 Protein General Information | |
|---|---|
| Alternate Names | |
| ; 5′-AMP-activated protein kinase subunit beta | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PRKAB2 |
| Entrez Gene ID | 5565 |
| Ensemble Gene ID | ENSG00000131791 |
| RefSeq Protein Accession(s) | NP_005390.1 |
| RefSeq mRNA Accession(s) | NM_005399.4 |
| UniProt ID(s) | O43741 |
| UniGene ID(s) | Hs.50732 |
| HGNC ID(s) | HGNC:9379 |
| COSMIC ID Link(s) | PRKAB2 |
| KEGG Gene ID(s) | hsa:5565 |
| PharmGKB ID(s) | PA33747 |
| General Description of Recombinant Human PRKAB2 Protein. | |
| Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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