PDF DatasheetHuman S-phase kinase-associated protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant S-phase kinase-associated protein 2 based upon sequence from: Human
Host: QP7528 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) S-phase kinase-associated protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7528.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu424
Amino Acid Sequence: MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK PSCL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human S-phase kinase-associated protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human S-phase kinase-associated protein 2 Protein General Information | |
|---|---|
| Alternate Names | |
| FBL1; p45; FLB1; FBXL1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SKP2 |
| Entrez Gene ID | 6502 |
| Ensemble Gene ID | ENSG00000145604 |
| RefSeq Protein Accession(s) | NP_001230049.1 |
| RefSeq mRNA Accession(s) | NM_001243120.1, NM_005983.3, NM_032637.3 |
| UniProt ID(s) | Q13309 |
| UniGene ID(s) | Hs.23348 |
| HGNC ID(s) | HGNC:10901 |
| COSMIC ID Link(s) | SKP2 |
| KEGG Gene ID(s) | hsa:6502 |
| PharmGKB ID(s) | PA35801 |
| General Description of Recombinant Human S-phase kinase-associated protein 2 Protein. | |
| Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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