PDF DatasheetHuman CIRBP / Cold-inducible RNA-binding Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CIRBP / Cold-inducible RNA-binding based upon sequence from: Human
Host: QP7529 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CIRBP / Cold-inducible RNA-binding, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7529.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CIRBP / Cold-inducible RNA-binding Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CIRBP / Cold-inducible RNA-binding Protein General Information | |
|---|---|
| Alternate Names | |
| CIRBP; Cold-inducible RNA-binding; CIRP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CIRBP |
| Entrez Gene ID | 1153 |
| Ensemble Gene ID | ENSG00000099622 |
| RefSeq Protein Accession(s) | NP_001271.1 |
| RefSeq mRNA Accession(s) | NM_001280.2, NM_001300815.1, NM_001300829.1, XM_006722637.1 |
| UniProt ID(s) | Q14011 |
| UniGene ID(s) | Hs.618145 |
| HGNC ID(s) | HGNC:1982 |
| COSMIC ID Link(s) | CIRBP |
| KEGG Gene ID(s) | hsa:1153 |
| PharmGKB ID(s) | PA26519 |
| General Description of Recombinant Human CIRBP / Cold-inducible RNA-binding Protein. | |
| Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3′-untranslated regions (3′-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.