PDF DatasheetHuman UDP-glucose 4-epimerase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant UDP-glucose 4-epimerase based upon sequence from: Human
Host: QP7531 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) UDP-glucose 4-epimerase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7531.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala348
Amino Acid Sequence: MAEKVLVTGG AGYIGSHTVL ELLEAGYLPV VIDNFHNAFR GGGSLPESLR RVQELTGRSV EFEEMDILDQ GALQRLFKKY SFMAVIHFAG LKAVGESVQK PLDYYRVNLT GTIQLLEIMK AHGVKNLVFS SSATVYGNPQ YLPLDEAHPT GGCTNPYGKS KFFIEEMIRD LCQADKTWNA VLLRYFNPTG AHASGCIGED PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD YIHVVDLAKG HIAALRKLKE QCGCRIYNLG TGTGYSVLQM VQAMEKASGK KIPYKVVARR EGDVAACYAN PSLAQEELGW TAALGLDRMC EDLWRWQKQN PSGFGTQA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human UDP-glucose 4-epimerase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human UDP-glucose 4-epimerase Protein General Information | |
|---|---|
| Alternate Names | |
| SDR1E1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GALE |
| Entrez Gene ID | 2582 |
| Ensemble Gene ID | ENSG00000117308 |
| RefSeq Protein Accession(s) | NP_000394.2 |
| RefSeq mRNA Accession(s) | NM_000403.3, NM_001008216.1, NM_001127621.1 |
| UniProt ID(s) | Q14376 |
| UniGene ID(s) | Hs.632380 |
| HGNC ID(s) | HGNC:4116 |
| COSMIC ID Link(s) | GALE |
| KEGG Gene ID(s) | hsa:2582 |
| PharmGKB ID(s) | PA28531 |
| General Description of Recombinant Human UDP-glucose 4-epimerase Protein. | |
| Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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