PDF DatasheetHuman Transcriptional enhancer factor TEF-4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcriptional enhancer factor TEF-4 based upon sequence from: Human
Host: QP7534 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcriptional enhancer factor TEF-4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7534.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Thr94 – Asp447
Amino Acid Sequence: TRTRKQVSSH IQVLARRKSR EIQSKLKDQV SKDKAFQTMA TMSSAQLISA PSLQAKLGPT GPQASELFQF WSGGSGPPWN VPDVKPFSQT PFTLSLTPPS TDLPGYEPPQ ALSPLPPPTP SPPAWQARGL GTARLQLVEF SAFVEPPDAV DSYQRHLFVH ISQHCPSPGA PPLESVDVRQ IYDKFPEKKG GLRELYDRGP PHAFFLVKFW ADLNWGPSGE EAGAGGSISS GGFYGVSSQY ESLEHMTLTC SSKVCSFGKQ VVEKVETERA QLEDGRFVYR LLRSPMCEYL VNFLHKLRQL PERYMMNSVL ENFTILQVVT NRDTQELLLC TAYVFEVSTS ERGAQHHIYR LVRD
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transcriptional enhancer factor TEF-4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transcriptional enhancer factor TEF-4 Protein (94-447aa) General Information | |
|---|---|
| Alternate Names | |
| TEF-4; TEAD-2; TEF4; ETF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TEAD2 |
| Entrez Gene ID | 8463 |
| Ensemble Gene ID | ENSG00000074219 |
| RefSeq Protein Accession(s) | NP_001243587.1 |
| RefSeq mRNA Accession(s) | NM_001256658.1, NM_001256659.1, NM_001256660.1, NM_001256661.1, NM_001256662.1, NM_003598.1, XM_006723424.1, XM_011527403.1 |
| UniProt ID(s) | Q15562 |
| UniGene ID(s) | Hs.515534 |
| HGNC ID(s) | HGNC:11715 |
| COSMIC ID Link(s) | TEAD2 |
| KEGG Gene ID(s) | hsa:8463 |
| PharmGKB ID(s) | PA36433 |
| General Description of Recombinant Human Transcriptional enhancer factor TEF-4 Protein (94-447aa). | |
| Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC ‘enhansons’ (5′-GTGGAATGT-3′). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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