PDF DatasheetHuman TXNRD1 / TRXR1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TXNRD1 / TRXR1 based upon sequence from: Human
Isoform: Isoform 5
Host: QP7539 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TXNRD1 / TRXR1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7539.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details). of Isoform 5
Expression Region: Met1 – Cys497
Amino Acid Sequence: MNGPEDLPKS YDYDLIIIGG GSGGLAAAKE AAQYGKKVMV LDFVTPTPLG TRWGLGGTCV NVGCIPKKLM HQAALLGQAL QDSRNYGWKV EETVKHDWDR MIEAVQNHIG SLNWGYRVAL REKKVVYENA YGQFIGPHRI KATNNKGKEK IYSAERFLIA TGERPRYLGI PGDKEYCISS DDLFSLPYCP GKTLVVGASY VALECAGFLA GIGLDVTVMV RSILLRGFDQ DMANKIGEHM EEHGIKFIRQ FVPIKVEQIE AGTPGRLRVV AQSTNSEEII EGEYNTVMLA IGRDACTRKI GLETVGVKIN EKTGKIPVTD EEQTNVPYIY AIGDILEDKV ELTPVAIQAG RLLAQRLYAG STVKCDYENV PTTVFTPLEY GACGLSEEKA VEKFGEENIE VYHSYFWPLE WTIPSRDNNK CYAKIICNTK DNERVVGFHV LGPNAGEVTQ GFAAALKCGL TKKQLDSTIG IHPVCAEVFT TLSVTKRSGA SILQAGC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TXNRD1 / TRXR1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TXNRD1 / TRXR1 Protein General Information | |
|---|---|
| Alternate Names | |
| TXNRD1; TRXR1; TRXR1; GRIM-12; TR1; TXNR; TR | |
| Molecular Weight | |
| Isoform 5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TXNRD1 |
| Entrez Gene ID | 7296 |
| Ensemble Gene ID | ENSG00000198431 |
| RefSeq Protein Accession(s) | NP_001087240.1 |
| RefSeq mRNA Accession(s) | NM_001093771.2, NM_001261445.1, NM_001261446.1, NM_003330.3, NM_182729.2, NM_182742.2, NM_182743.2 |
| UniProt ID(s) | Q16881 |
| UniGene ID(s) | Hs.654922 |
| HGNC ID(s) | HGNC:12437 |
| COSMIC ID Link(s) | TXNRD1 |
| KEGG Gene ID(s) | hsa:7296 |
| PharmGKB ID(s) | PA37093 |
| General Description of Recombinant Human TXNRD1 / TRXR1 Protein. | |
| Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell mbrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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