PDF DatasheetHuman DNA repair protein XRCC4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA repair protein XRCC4 based upon sequence from: Human
Host: QP7540 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA repair protein XRCC4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7540.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MERKISRIHL VSEPSITHFL QVSWEKTLES GFVITLTDGH SAWTGTVSES EISQEADDMA MEKGKYVGEL RKALLSGAGP ADVYTFNFSK ESCYFFFEKN LKDVSFRLGS FNLEKVENPA EVIRELICYC LDTIAENQAK NEHLQKENER LLRDWNDVQG RFEKCVSAKE ALETDLYKRF ILVLNEKKTK IRSLHNKLLN AAQEREKDIK QEGETAICSE MTADRDPVYD ESTDEESENQ TDLSGLASAA VSKDDSIISS LDVTDIAPSR KRRQRMQRNL GTEPKMAPQE NQLQEKENSR PDSSLPETSK KEHISAENMS LETLRNSSPE DLFDEI
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DNA repair protein XRCC4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA repair protein XRCC4 Protein General Information | |
|---|---|
| Alternate Names | |
| SSMED | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | XRCC4 |
| Entrez Gene ID | 7518 |
| Ensemble Gene ID | ENSG00000152422 |
| RefSeq Protein Accession(s) | NP_001304941.1 |
| RefSeq mRNA Accession(s) | NM_001318012.1, NM_001318013.1, NM_003401.4, NM_022406.3, NM_022550.3, XM_011543626.1 |
| UniProt ID(s) | Q13426 |
| UniGene ID(s) | Hs.567359 |
| HGNC ID(s) | HGNC:12831 |
| COSMIC ID Link(s) | XRCC4 |
| KEGG Gene ID(s) | hsa:7518 |
| PharmGKB ID(s) | PA37423 |
| General Description of Recombinant Human DNA repair protein XRCC4 Protein. | |
| Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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