PDF DatasheetHuman RAB31 / Rab22B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant RAB31 / Rab22B based upon sequence from: Human
Host: QP7541 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RAB31 / Rab22B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7541.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Cys194
Amino Acid Sequence: MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human RAB31 / Rab22B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human RAB31 / Rab22B Protein General Information | |
|---|---|
| Alternate Names | |
| RAB31; Rab22B; Rab22B | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAB31 |
| Entrez Gene ID | 11031 |
| Ensemble Gene ID | ENSG00000168461 |
| RefSeq Protein Accession(s) | NP_006859.2 |
| RefSeq mRNA Accession(s) | NM_006868.3 |
| UniProt ID(s) | Q13636 |
| UniGene ID(s) | Hs.744887 |
| HGNC ID(s) | HGNC:9771 |
| COSMIC ID Link(s) | RAB31 |
| KEGG Gene ID(s) | hsa:11031 |
| PharmGKB ID(s) | PA34122 |
| General Description of Recombinant Human RAB31 / Rab22B Protein. | |
| The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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