PDF DatasheetHuman Baculoviral IAP repeat-containing protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Baculoviral IAP repeat-containing protein 1 based upon sequence from: Human
Host: QP7547 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Baculoviral IAP repeat-containing protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7547.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu60 – Leu345
Amino Acid Sequence: EAKRLKTFVT YEPYSSWIPQ EMAAAGFYFT GVKSGIQCFC CSLILFGAGL TRLPIEDHKR FHPDCGFLLN KDVGNIAKYD IRVKNLKSRL RGGKMRYQEE EARLASFRNW PFYVQGISPC VLSEAGFVFT GKQDTVQCFS CGGCLGNWEE GDDPWKEHAK WFPKCEFLRS KKSSEEITQY IQSYKGFVDI TGEHFVNSWV QRELPMASAY CNDSIFAYEE LRLDSFKDWP RESAVGVAAL AKAGLFYTGI KDIVQCFSCG GCLEKWQEGD DPLDDHTRCF PNCPFL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Baculoviral IAP repeat-containing protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Baculoviral IAP repeat-containing protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| NLRB1; psiNAIP; BIRC1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NAIP |
| Entrez Gene ID | 4671 |
| Ensemble Gene ID | ENSG00000249437 |
| RefSeq Protein Accession(s) | NP_001333799.1 |
| RefSeq mRNA Accession(s) | NM_001346870.1, NM_004536.2, NM_022892.1 |
| UniProt ID(s) | Q13075 |
| UniGene ID(s) | Hs.646951 |
| HGNC ID(s) | HGNC:7634 |
| COSMIC ID Link(s) | NAIP |
| KEGG Gene ID(s) | hsa:4671 |
| PharmGKB ID(s) | PA162396805 |
| General Description of Recombinant Human Baculoviral IAP repeat-containing protein 1 Protein. | |
| Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ‘Asp-315’ and decreasing the rate of auto proteolysis at ‘Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that ses to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assbly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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