PDF DatasheetHuman DHRS2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DHRS2 based upon sequence from: Human
Isoform: Isoform 2
Host: QP7548 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DHRS2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7548.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Ala300
Amino Acid Sequence: MLSAVARGYQ GWFHPCARLS VRMSSTGIDR KGVLANRVAV VTGSTSGIGF AIARRLARDG AHVVISSRKQ QNVDRAMAKL QGEGLSVAGI VCHVGKAEDR EQLVAKALEH CGGVDFLVCS AGVNPLVGST LGTSEQIWDK ILSVNVKSPA LLLSQLLPYM ENRRGAVILV SSIAAYNPVV ALGVYNVSKT ALLGLTRTLA LELAPKDIRV NCVVPGIIKT DFSKVVRIGF MGMSLSGRTS RNIISCRGLG SQRTVQESCP SCALQMPATS TGRTLRWQAT PLGSERSGGG CVAVVPGPGA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DHRS2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DHRS2 Protein General Information | |
|---|---|
| Alternate Names | |
| SDR25C1; HEP27; Dehydrogenase/reductase SDR family member 2, mitochondri | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DHRS2 |
| Entrez Gene ID | 10202 |
| Ensemble Gene ID | ENSG00000100867 |
| RefSeq Protein Accession(s) | NP_005785.1 |
| RefSeq mRNA Accession(s) | NM_005794.3, NM_182908.4, XM_005267249.1, XM_006720001.3 |
| UniProt ID(s) | Q13268 |
| UniGene ID(s) | Hs.272499 |
| HGNC ID(s) | HGNC:18349 |
| COSMIC ID Link(s) | DHRS2 |
| KEGG Gene ID(s) | hsa:10202 |
| PharmGKB ID(s) | PA38318 |
| General Description of Recombinant Human DHRS2 Protein. | |
| Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.