Human MBTPS1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MBTPS1 based upon sequence from: Human
Host: QP7551 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MBTPS1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7551.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp218 – Ser414
Amino Acid Sequence: DTGLSEKHPH FKNVKERTNW TNERTLDDGL GHGTFVAGVI ASMRECQGFA PDAELHIFRV FTNNQVSYTS WFLDAFNYAI LKKIDVLNLS IGGPDFMDHP FVDKVWELTA NNVIMVSAIG NDGPLYGTLN NPADQMDVIG VGGIDFEDNI ARFSSRGMTT WELPGGYGRM KPDIVTYGAG VRGSGVKGGC RALSGTS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human MBTPS1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
Recombinant Human MBTPS1 Protein General Information | |
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Alternate Names | |
PCSK8; S1P; SKI-1; Membrane-bound transcription factor site-1 protea | |
Curated Database and Bioinformatic Data | |
Gene Symbol | MBTPS1 |
Entrez Gene ID | 8720 |
Ensemble Gene ID | ENSG00000140943 |
RefSeq Protein Accession(s) | NP_003782.1 |
RefSeq mRNA Accession(s) | NM_003791.3 |
UniProt ID(s) | Q14703 |
UniGene ID(s) | Hs.75890 |
HGNC ID(s) | HGNC:15456 |
COSMIC ID Link(s) | MBTPS1 |
KEGG Gene ID(s) | hsa:8720 |
PharmGKB ID(s) | PA30671 |
General Description of Recombinant Human MBTPS1 Protein. | |
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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