PDF DatasheetHuman Septin-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Septin-2 based upon sequence from: Human
Host: QP7552 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Septin-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7552.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val361
Amino Acid Sequence: MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK STLINSLFLT DLYPERVIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV DTPGYGDAIN CRDCFKTIIS YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL KPLDVAFMKA IHNKVNIVPV IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG DGDGGALGHH V
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Septin-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Septin-2 Protein General Information | |
|---|---|
| Alternate Names | |
| Pnutl3; hNedd5; DIFF6; NEDD5; NEDD-5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 42980 |
| Entrez Gene ID | 4735 |
| Ensemble Gene ID | ENSG00000168385 |
| RefSeq Protein Accession(s) | NP_001008491.1 |
| RefSeq mRNA Accession(s) | NM_001008491.2, NM_001008492.2, NM_001282972.1, NM_001282973.1, NM_001321029.1, NM_001321030.1, NM_001321031.1, NM_001321032.1, NM_001321033.1, NM_001321034.1, NM_001321035.1, NM_004404.4, NM_006155.2, XM_017004205.1, XM_017004206.1 |
| UniProt ID(s) | Q15019 |
| UniGene ID(s) | Hs.721234 |
| HGNC ID(s) | HGNC:7729 |
| KEGG Gene ID(s) | hsa:4735 |
| PharmGKB ID(s) | PA31535 |
| General Description of Recombinant Human Septin-2 Protein. | |
| Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.