PDF DatasheetHuman NEDD8 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NEDD8 based upon sequence from: Human
Host: QP7554 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NEDD8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7554.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK ILGGSVLHLV LALRGG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NEDD8 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NEDD8 Protein General Information | |
|---|---|
| Alternate Names | |
| NEDD-8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NEDD8 |
| Entrez Gene ID | 4738 |
| Ensemble Gene ID | ENSG00000129559 |
| RefSeq Protein Accession(s) | NP_006147.1 |
| RefSeq mRNA Accession(s) | NM_006156.2 |
| UniProt ID(s) | Q15843 |
| UniGene ID(s) | Hs.531064 |
| HGNC ID(s) | HGNC:7732 |
| COSMIC ID Link(s) | NEDD8 |
| KEGG Gene ID(s) | hsa:4738 |
| PharmGKB ID(s) | PA31537 |
| General Description of Recombinant Human NEDD8 Protein. | |
| Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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