PDF DatasheetHuman Nuclear inhibitor of protein phosphatase 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Nuclear inhibitor of protein phosphatase 1 based upon sequence from: Human
Isoform: Isoform 2
Host: QP7556 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Nuclear inhibitor of protein phosphatase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7556.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Gly209
Amino Acid Sequence: MGGEDDELKG LLGLPEEETE LDNLTEFNTA HNKRISTLTI EEGNLDIQRP KRKRKNSRVT FSEDDEIINP EDVDPSVGRF RNMVQTAVVP VKKKRVEGPG SLGLEESGSR RMQNFAFSGG LYGGLPPTHS EAGSQPHGIH GTALIGGLPM PYPNLAPDVD LTPVVPSAVN MNPAPNPAVY NPEAVNEPKK KKYAKEAWPG KKPTPSLLIL ENGTHMASSD ACHECKSMIA AAG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Nuclear inhibitor of protein phosphatase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Nuclear inhibitor of protein phosphatase 1 Protein General Information | |
|---|---|
| Alternate Names | |
| PRO2047; NIPP-1; ARD-1; ARD1; NIPP1 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPP1R8 |
| Entrez Gene ID | 5511 |
| Ensemble Gene ID | ENSG00000117751 |
| RefSeq Protein Accession(s) | NP_002704.1 |
| RefSeq mRNA Accession(s) | NM_002713.3, NM_014110.4, NM_138558.2, XM_017001594.1 |
| UniProt ID(s) | Q12972 |
| UniGene ID(s) | Hs.533474 |
| HGNC ID(s) | HGNC:9296 |
| COSMIC ID Link(s) | PPP1R8 |
| KEGG Gene ID(s) | hsa:5511 |
| PharmGKB ID(s) | PA33659 |
| General Description of Recombinant Human Nuclear inhibitor of protein phosphatase 1 Protein. | |
| Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3′ to purines and pyrimidines in A+U-rich regions. It generates 5′-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. |
|
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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