PDF DatasheetHuman AIMP2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant AIMP2 based upon sequence from: Human
Host: QP7558 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) AIMP2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7558.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys320
Amino Acid Sequence: MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ RWMRSCENLA PFNTALKLLK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human AIMP2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human AIMP2 Protein General Information | |
|---|---|
| Alternate Names | |
| P38; JTV-1; JTV1; Aminoacyl tRNA synthase complex-interacting multifunctional protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AIMP2 |
| Entrez Gene ID | 7965 |
| Ensemble Gene ID | ENSG00000106305 |
| RefSeq Protein Accession(s) | NP_006294.2 |
| RefSeq mRNA Accession(s) | NM_006303.3 |
| UniProt ID(s) | Q13155 |
| UniGene ID(s) | Hs.301613 |
| HGNC ID(s) | HGNC:20609 |
| COSMIC ID Link(s) | AIMP2 |
| KEGG Gene ID(s) | hsa:7965 |
| PharmGKB ID(s) | PA165617609 |
| General Description of Recombinant Human AIMP2 Protein. | |
| Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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