PDF DatasheetHuman Oxysterols receptor LXR-alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Oxysterols receptor LXR-alpha based upon sequence from: Human
Isoform: Isoform 3
Host: QP7567 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Oxysterols receptor LXR-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7567.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 3
Expression Region: Met1 – Glu40
Amino Acid Sequence: MPHSAGGTAG VGLEAAEPTA LLTRAEPPSE PTEIRPQKRK KGPAPKMLGN ELCSVCGDKA SGFHYNVLSC EGCKGFFRRS VIKGAHYICH SGGHCPMDTY MRRKCQECRL RKCRQAGMRE ECVLSEEQIR LKKLKRQEEE QAHATSLPPR ASSPPQILPQ LSPEQLGMIE KLVAAQQQCN RRSFSDRLRV TPWPMAPDPH SREARQQRFA HFTELAIVSV QEIVDFAKQL PGFLQLSRED QIALLKTSAI EVMLLETSRR YNPGSESITF LKDFSYNRED FAKAGLQVEF INPIFEFSRA MNELQLNDAE FALLIAISIF SADRPNVQDQ LQVERLQHTY VEALHAYVSI HHPHDRLMFP RMLMKLVSLR TLSSVHSEQV FALRLQDKKL PPLLSEIWDV HE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Oxysterols receptor LXR-alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Oxysterols receptor LXR-alpha Protein General Information | |
|---|---|
| Alternate Names | |
| LXRA; RLD-1; LXR-a | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NR1H3 |
| Entrez Gene ID | 10062 |
| Ensemble Gene ID | ENSG00000025434 |
| RefSeq Protein Accession(s) | NP_001123573.1 |
| RefSeq mRNA Accession(s) | NM_001130101.2, NM_001130102.2, NM_005693.3, XM_005252705.1, XM_005252706.1, XM_005252707.4, XM_005252709.1, XM_005252710.1, XM_005252713.3, XM_006718112.1, XM_006718113.1, XM_006718115.1, XM_006718116.1, XM_011519805.2, XM_017017058.1 |
| UniProt ID(s) | Q13133 |
| UniGene ID(s) | Hs.438863 |
| HGNC ID(s) | HGNC:7966 |
| COSMIC ID Link(s) | NR1H3 |
| KEGG Gene ID(s) | hsa:10062 |
| PharmGKB ID(s) | PA31751 |
| General Description of Recombinant Human Oxysterols receptor LXR-alpha Protein. | |
| Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elents characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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