PDF DatasheetHuman MAD2L1 / MAD2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MAD2L1 / MAD2 based upon sequence from: Human
Host: QP7568 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MAD2L1 / MAD2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7568.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Asp205
Amino Acid Sequence: ALQLSREQGI TLRGSAEIVA EFFSFGINSI LYQRGIYPSE TFTRVQKYGL TLLVTTDLEL IKYLNNVVEQ LKDWLYKCSV QKLVVVISNI ESGEVLERWQ FDIECDKTAK DDSAPREKSQ KAIQDEIRSV IRQITATVTF LPLLEVSCSF DLLIYTDKDL VVPEKWEESG PQFITNSEEV RLRSFTTTIH KVNSMVAYKI PVND
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human MAD2L1 / MAD2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MAD2L1 / MAD2 Protein General Information | |
|---|---|
| Alternate Names | |
| MAD2L1; MAD2; HSMAD2; MAD2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MAD2L1 |
| Entrez Gene ID | 4085 |
| Ensemble Gene ID | ENSG00000164109 |
| RefSeq Protein Accession(s) | NP_002349.1 |
| RefSeq mRNA Accession(s) | NM_002358.3 |
| UniProt ID(s) | Q13257 |
| UniGene ID(s) | Hs.591697 |
| HGNC ID(s) | HGNC:6763 |
| COSMIC ID Link(s) | MAD2L1 |
| KEGG Gene ID(s) | hsa:4085 |
| PharmGKB ID(s) | PA30521 |
| General Description of Recombinant Human MAD2L1 / MAD2 Protein. | |
| Component of the spindle-assbly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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