PDF DatasheetHuman TCEB2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TCEB2 based upon sequence from: Human
Host: QP7575 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TCEB2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7575.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TCEB2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TCEB2 Protein General Information | |
|---|---|
| Alternate Names | |
| SIII; TCEB2; Transcription elongation factor B polypeptide | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TCEB2 |
| Entrez Gene ID | 6923 |
| Ensemble Gene ID | ENSG00000103363 |
| RefSeq Protein Accession(s) | NP_009039.1 |
| RefSeq mRNA Accession(s) | NM_007108.3, NM_207013.2 |
| UniProt ID(s) | Q15370 |
| UniGene ID(s) | Hs.172772 |
| HGNC ID(s) | HGNC:11619 |
| COSMIC ID Link(s) | TCEB2 |
| KEGG Gene ID(s) | hsa:6923 |
| PharmGKB ID(s) | PA36378 |
| General Description of Recombinant Human TCEB2 Protein. | |
| SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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