PDF DatasheetHuman TRADD Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TRADD based upon sequence from: Human
Host: QP7583 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TRADD, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7583.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLTDPNGG LA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TRADD Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TRADD Protein General Information | |
|---|---|
| Alternate Names | |
| Hs.89862; Tumor necrosis factor receptor type 1-associated DEATH domain prote | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRADD |
| Entrez Gene ID | 8717 |
| Ensemble Gene ID | ENSG00000102871 |
| RefSeq Protein Accession(s) | NP_001310481.1 |
| RefSeq mRNA Accession(s) | NM_001323552.1, NM_003789.3, XM_005256213.3, XM_017023815.1 |
| UniProt ID(s) | Q15628 |
| UniGene ID(s) | Hs.460996 |
| HGNC ID(s) | HGNC:12030 |
| COSMIC ID Link(s) | TRADD |
| KEGG Gene ID(s) | hsa:8717 |
| PharmGKB ID(s) | PA36707 |
| General Description of Recombinant Human TRADD Protein. | |
| The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.