PDF DatasheetHuman Centromere protein R Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Centromere protein R based upon sequence from: Human
Host: QP7591 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Centromere protein R, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7591.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn177
Amino Acid Sequence: MPVKRSLKLD GLLEENSFDP SKITRKKSVI TYSPTTGTCQ MSLFASPTSS EEQKHRNGLS NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI MEIMQNLSSI QALEGSRELE NLIGISCASH FLKREMQKTK ELMTKVNKQK LFEKSTGLPH KASRHLDSYE FLKAILN
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Centromere protein R Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Centromere protein R Protein General Information | |
|---|---|
| Alternate Names | |
| TAP20; CENP-R; CENPR; NRIF3; HSU37139 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ITGB3BP |
| Entrez Gene ID | 23421 |
| Ensemble Gene ID | ENSG00000142856 |
| RefSeq Protein Accession(s) | NP_001193668.1 |
| RefSeq mRNA Accession(s) | NM_001206739.1, NM_001347148.1, NM_014288.4 |
| UniProt ID(s) | Q13352 |
| UniGene ID(s) | Hs.166539 |
| HGNC ID(s) | HGNC:6157 |
| COSMIC ID Link(s) | ITGB3BP |
| KEGG Gene ID(s) | hsa:23421 |
| PharmGKB ID(s) | PA29956 |
| General Description of Recombinant Human Centromere protein R Protein. | |
| Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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