PDF DatasheetHuman Unconventional myosin-VIIa Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Unconventional myosin-VIIa based upon sequence from: Human
Host: QP7592 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Unconventional myosin-VIIa, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7592.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Trp838 – Glu968
Amino Acid Sequence: WAVLTVQAYA RGMIARRLHQ RLRAEYLWRL EAEKMRLAEE EKLRKEMSAK KAKEEAERKH QERLAQLARE DAERELKEKE AARRKKELLE QMERARHEPV NHSDMVDKMF GFLGTSGGLP GQEGQAPSGF E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Unconventional myosin-VIIa Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Unconventional myosin-VIIa Protein General Information | |
|---|---|
| Alternate Names | |
| MYU7A; USH1B; DFNA11; DFNB2; MYOVIIA; NSRD2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MYO7A |
| Entrez Gene ID | 4647 |
| Ensemble Gene ID | ENSG00000137474 |
| RefSeq Protein Accession(s) | NP_000251.3 |
| RefSeq mRNA Accession(s) | NM_000260.3, NM_001127179.2, NM_001127180.1 |
| UniProt ID(s) | Q13402 |
| UniGene ID(s) | Hs.370421 |
| HGNC ID(s) | HGNC:7606 |
| COSMIC ID Link(s) | MYO7A |
| KEGG Gene ID(s) | hsa:4647 |
| PharmGKB ID(s) | PA31411 |
| General Description of Recombinant Human Unconventional myosin-VIIa Protein. | |
| Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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