PDF DatasheetHuman Glucokinase regulatory protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glucokinase regulatory protein based upon sequence from: Human
Host: QP7596 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glucokinase regulatory protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7596.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln625
Amino Acid Sequence: MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA VRSALAGPGQ KRTADPLEIL EPDVQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Glucokinase regulatory protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glucokinase regulatory protein Protein General Information | |
|---|---|
| Alternate Names | |
| FGQTL5; GKRP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GCKR |
| Entrez Gene ID | 2646 |
| Ensemble Gene ID | ENSG00000084734 |
| RefSeq Protein Accession(s) | NP_001477.2 |
| RefSeq mRNA Accession(s) | NM_001486.3 |
| UniProt ID(s) | Q14397 |
| UniGene ID(s) | Hs.89771 |
| HGNC ID(s) | HGNC:4196 |
| COSMIC ID Link(s) | GCKR |
| KEGG Gene ID(s) | hsa:2646 |
| PharmGKB ID(s) | PA28611 |
| General Description of Recombinant Human Glucokinase regulatory protein Protein. | |
| Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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