PDF DatasheetHuman RISC-loading complex subunit TARBP2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant RISC-loading complex subunit TARBP2 based upon sequence from: Human
Host: QP7601 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RISC-loading complex subunit TARBP2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7601.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL LKAEGQAHQP NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM LEPALEDSSS FSPLDSSLPE DIPVFTAAAA ATPVPSVVLT RSPPMELQPP VSPQQSECNP VGALQELVVQ KGWRLPEYTV TQESGPAHRK EFTMTCRVER FIEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEVEP DDDHFSIGVG SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGSLGAL GPACCRVLSE LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS ATTREAARGE AARRALQYLK IMAGSK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human RISC-loading complex subunit TARBP2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human RISC-loading complex subunit TARBP2 Protein General Information | |
|---|---|
| Alternate Names | |
| TRBP; TRBP1; TRBP2; LOQS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TARBP2 |
| Entrez Gene ID | 6895 |
| Ensemble Gene ID | ENSG00000139546 |
| RefSeq Protein Accession(s) | NP_004169.3 |
| RefSeq mRNA Accession(s) | NM_004178.4, NM_134323.1, NM_134324.2, XM_005269114.1, XM_005269115.2 |
| UniProt ID(s) | Q15633 |
| UniGene ID(s) | Hs.326 |
| HGNC ID(s) | HGNC:11569 |
| COSMIC ID Link(s) | TARBP2 |
| KEGG Gene ID(s) | hsa:6895 |
| PharmGKB ID(s) | PA36334 |
| General Description of Recombinant Human RISC-loading complex subunit TARBP2 Protein. | |
| Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.