PDF DatasheetHuman Secretory phospholipase A2 receptor Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Secretory phospholipase A2 receptor based upon sequence from: Human
Host: QP7606 protein expressed in E.coli, Yeast, Mammal..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Secretory phospholipase A2 receptor, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7606.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu395 – Asp530
Amino Acid Sequence: EEKTWHEALR SCQADNSALI DITSLAEVEF LVTLLGDENA SETWIGLSSN KIPVSFEWSN DSSVIFTNWH TLEPHIFPNR SQLCVSAEQS EGHWKVKNCE ERLFYICKKA GHVLSDAESG CQEGWERHGG FCYKID
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Secretory phospholipase A2 receptor Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Secretory phospholipase A2 receptor Protein General Information | |
|---|---|
| Alternate Names | |
| CLEC13C; PLA2-R; PLA2IR; PLA2G1R; PLA2R | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLA2R1 |
| Entrez Gene ID | 22925 |
| Ensemble Gene ID | ENSG00000153246 |
| RefSeq Protein Accession(s) | NP_001007268.1 |
| RefSeq mRNA Accession(s) | NM_001007267.2, NM_001195641.1, NM_007366.4, XM_005246392.3, XM_011510820.2, XM_017003598.1 |
| UniProt ID(s) | Q13018 |
| UniGene ID(s) | Hs.410477 |
| HGNC ID(s) | HGNC:9042 |
| COSMIC ID Link(s) | PLA2R1 |
| KEGG Gene ID(s) | hsa:22925 |
| PharmGKB ID(s) | PA33369 |
| General Description of Recombinant Human Secretory phospholipase A2 receptor Protein. | |
| Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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