PDF DatasheetHuman Mediator of DNA damage checkpoint protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Mediator of DNA damage checkpoint protein 1 based upon sequence from: Human
Host: QP7613 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Mediator of DNA damage checkpoint protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7613.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala1892 – Ser2082
Amino Acid Sequence: APKVLFTGVV DARGERAVLA LGGSLAGSAA EASHLVTDRI RRTVKFLCAL GRGIPILSLD WLHQSRKAGF FLPPDEYVVT DPEQEKNFGF SLQDALSRAR ERRLLEGYEI YVTPGVQPPP PQMGEIISCC GGTYLPSMPR SYKPQRVVIT CPQDFPHCSI PLRVGLPLLS PEFLLTGVLK QEAKPEAFVL S
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Mediator of DNA damage checkpoint protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Mediator of DNA damage checkpoint protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| NFBD1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MDC1 |
| Entrez Gene ID | 9656 |
| Ensemble Gene ID | ENSG00000137337 |
| RefSeq Protein Accession(s) | NP_055456.2 |
| RefSeq mRNA Accession(s) | NM_014641.2, XM_005249494.4, XM_011515001.2, XM_011515003.2, XM_017011519.1 |
| UniProt ID(s) | Q14676 |
| UniGene ID(s) | Hs.653495 |
| HGNC ID(s) | HGNC:21163 |
| COSMIC ID Link(s) | MDC1 |
| KEGG Gene ID(s) | hsa:9656 |
| PharmGKB ID(s) | PA134942837 |
| General Description of Recombinant Human Mediator of DNA damage checkpoint protein 1 Protein. | |
| Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ‘Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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