PDF DatasheetHuman SART3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SART3 based upon sequence from: Human
Host: QP7616 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SART3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7616.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gln600 – Pro900
Amino Acid Sequence: QRKRARAEKK ALKKKKKIRG PEKRGADEDD EKEWGDDEEE QPSKRRRVEN SIPAAGETQN VEVAAGPAGK CAAVDVEPPS KQKEKAASLK RDMPKVLHDS SKDSITVFVS NLPYSMQEPD TKLRPLFEAC GEVVQIRPIF SNRGDFRGYC YVEFKEEKSA LQALEMDRKS VEGRPMFVSP CVDKSKNPDF KVFRYSTSLE KHKLFISGLP FSCTKEELEE ICKAHGTVKD LRLVTNRAGK PKGLAYVEYE NESQASQAVM KMDGMTIKEN IIKVAISNPP QRKVPEKPET RKAPGGPMLL P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SART3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SART3 Protein General Information | |
|---|---|
| Alternate Names | |
| p110(nrb); RP11-13G14; P100; TIP110; DSAP1; p110; Squamous cell carcinoma antigen recognized by T-cells | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SART3 |
| Entrez Gene ID | 9733 |
| Ensemble Gene ID | ENSG00000075856 |
| RefSeq Protein Accession(s) | NP_055521.1 |
| RefSeq mRNA Accession(s) | NM_014706.3 |
| UniProt ID(s) | Q15020 |
| UniGene ID(s) | Hs.584842 |
| HGNC ID(s) | HGNC:16860 |
| COSMIC ID Link(s) | SART3 |
| KEGG Gene ID(s) | hsa:9733 |
| PharmGKB ID(s) | PA34948 |
| General Description of Recombinant Human SART3 Protein. | |
| U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassbly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assbly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassbly . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair . May play a role in hatopoiesis probably through transcription regulation of specific genes including MYC . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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