PDF DatasheetHuman Josephin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Josephin-1 based upon sequence from: Human
Host: QP7617 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Josephin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7617.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val202
Amino Acid Sequence: MSCVPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRDTLQEIF QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM NLPSSLCWGP LKLPLKRQHW ICVREVGGAY YNLDSKLKMP EWIGGESELR KFLKHHLRGK NCELLLVVPE EVEAHQSWRT DV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Josephin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Josephin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| dJ508I15.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | JOSD1 |
| Entrez Gene ID | 9929 |
| Ensemble Gene ID | ENSG00000100221 |
| RefSeq Protein Accession(s) | NP_055691.1 |
| RefSeq mRNA Accession(s) | NM_014876.5, XM_005261876.2, XM_005261877.2, XM_005261878.2, XM_005261879.2 |
| UniProt ID(s) | Q15040 |
| UniGene ID(s) | Hs.3094 |
| HGNC ID(s) | HGNC:28953 |
| COSMIC ID Link(s) | JOSD1 |
| KEGG Gene ID(s) | hsa:9929 |
| PharmGKB ID(s) | PA142671644 |
| General Description of Recombinant Human Josephin-1 Protein. | |
| Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves ‘Lys-63’-linked and ‘Lys-48’-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance mbrane dynamics and cell motility independently of its catalytic activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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