PDF DatasheetMouse Cd163 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cd163 based upon sequence from: Mouse
Host: QP7641 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Cd163, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7641.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val86 – Ser365
Amino Acid Sequence: VVCQQLGCPT SIKALGWANS SAGSGYIWMD KVSCTGNESA LWDCKHDGWG KHNCTHEKDA GVTCSDGSNL EMRLVNSAGH RCLGRVEIKF QGKWGTVCDD NFSKDHASVI CKQLGCGSAI SFSGSAKLGA GSGPIWLDDL ACNGNESALW DCKHRGWGKH NCDHAEDVGV ICLEGADLSL RLVDGVSRCS GRLEVRFQGE WGTVCDDNWD LRDASVVCKQ LGCPTAISAI GRVNASEGSG QIWLDNISCE GHEATLWECK HQEWGKHYCH HREDAGVTCS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Cd163 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Cd163 Protein General Information | |
|---|---|
| Alternate Names | |
| CD163v2; CD163v3; Scavenger receptor cysteine-rich type 1 protein M1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Cd163 |
| Entrez Gene ID | 93671 |
| Ensemble Gene ID | ENSMUSG00000008845 |
| RefSeq Protein Accession(s) | NP_444324.2 |
| RefSeq mRNA Accession(s) | NM_053094.2 |
| UniProt ID(s) | Q2VLH6 |
| UniGene ID(s) | Mm.37426 |
| COSMIC ID Link(s) | Cd163 |
| KEGG Gene ID(s) | mmu:93671 |
| General Description of Recombinant Mouse Cd163 Protein. | |
| Involved in clearance and endocytosis of hoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hoglobin/haptoglobin and subsequent breakdown of he. Binds hoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 .After shedding, the soluble form (sCD163) may play an anti-inflammatory role. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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